Regulation of Ci-SCFSlimb Binding, Ci Proteolysis, and Hedgehog Pathway Activity by Ci Phosphorylation
نویسندگان
چکیده
منابع مشابه
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.
Hedgehog (Hh) proteins signal by inhibiting the proteolytic processing of Ci/Gli family transcription factors and by increasing Ci/Gli-specific activity. When Hh is absent, phosphorylation of Ci/Gli triggers binding to SCF ubiquitin ligase complexes and consequent proteolysis. Here we show that multiple successively phosphorylated CK1 sites on Ci create an atypical extended binding site for the...
متن کاملCi Proteolysis: Regulation by a Constellation of Phosphorylation Sites
Proteolytic processing of Ci requires phosphorylation by the kinases Sgg/GSK3 and CK1. The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylation by Sgg/GSK3 and CK1.
متن کاملHedgehog signalling: Ci complex cuts and clasps
Hedgehog (Hh) signalling in Drosophila inhibits partial proteolysis of the transcription factor Cubitus interruptus (Ci), and the ability of a complex containing Ci and the kinesin-related protein Costal-2 to bind microtubules. These changes are proposed to turn Ci from a repressor to an activator of Hh-target genes.
متن کاملQuotients of CI-Groups are CI-Groups
We show that a quotient group of a CI-group with respect to (di)graphs is a CI-group with respect to (di)graphs. In [1,2], Babai and Frankl provided strong constraints on which finite groups could be CI-groups with respect to graphs. As a tool in this program, they proved [1, Lemma 3.5] that a quotient group G/N of a CI-group G with respect to graphs is a CI-group with respect to graphs provide...
متن کاملDeubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.
Hedgehog (Hh) signaling plays essential roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and cancers. Regulation of the ubiquitin/proteasome-mediated proteolysis of Ci/Gli transcription factors is central to Hh signaling, but whether deubiquitinase is involved in this process remains unknown. Here, we show that Hh stimulates the binding of a u...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2007
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2007.09.006